Selected Publications in Personalized Intelligent Medicine

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Popular Articles

Lloyd E. Arresting sudden cardiac death. PittMed Magazine, October 2000.

Frank Raczkiewicz. University of Pittsburgh researchers develop computer system to predict impending arrhythmia and sudden death. PITTSBURGH, April 19, 2000.  http://newsbureau.upmc.com/Medsurg1/CardiacArrhythmiasComputers.htm.

Read also: http://www.sciencedaily.com/releases/2000/04/000421083512.htm
 

Scientific Articles

Shusterman V, Shtark M. Dynamic expert systems and biofeedback. Optoelectronics, Instrumentation and Data Processing 1993; 2: 62-68.

Shusterman V, Trofimov O. Building and application of expert systems for differential diagnostics of cardiovascular diseases.  Systems Analysis Modeling Simulation 1994; 14:15-24.

Shusterman V, Barnea O.  Spectral characteristics of skin temperature indicate peripheral stress-response.  Biofeedback and Self-Regulation 1995; 20: 357-367.

Shusterman V, Anderson KP, Barnea O. Spontaneous skin temperature oscillations in normal human subjects. American Journal of Physiology 1997; 273 (Regulatory Integrative Comp Physiol. 42): R1173-R1181.

Shusterman V, Aysin B, Gottipaty V, Weiss R, Brode S. Schwartzman D, Anderson KP. for the ESVEM Investigators. Autonomic nervous system activity and the spontaneous initiation of ventricular tachycardia. J Am Coll Cardiol, 1998; 32:1891-9.

Anderson KP, Shusterman V, Aysin B, Weiss R, Brode S, Gottipaty V. Distinctive RR dynamics preceding two modes of onset of spontaneous sustained ventricular tachycardia. Journal of Cardiovascular Electrophysiology, 1999; 10:897-904.

Shusterman V, Beigel A, Shah SI, Aysin B, Weiss R, Gottipaty VK, Schwartzman D, Anderson KP. Changes in autonomic activity and ventricular repolarization. Journal of Electrocardiology, 1999; 32:185-192.

Shusterman V, Aysin B, Weiss R, Brode S, Gottipaty V, Schwartzman D, Anderson KP. Dynamics of the low frequency RR-interval oscillations preceding spontaneous ventricular tachycardia. American Heart Journal, 2000: 139:126-33.

Shusterman V, Shah SI, Beigel A, Anderson KP. Enhancing the precision of ECG baseline correction: selective filtering and removal of residual error. Computers and Biomedical Research, 2000; 33: 144-160.

Shusterman V, Aysin B, Anderson KP, Beigel A. Multidimensional rhythm disturbances as a precursor of sustained ventricular tachyarrhythmias. Circulation Research, 2001; 88: 705-712.

Shusterman V, Usiene I, Harrigal C, Lee JS, Kubota T, Feldman AM, London B.Strain-Specific Patterns of Cardiac Rhythm, Autonomic Nervous System Activity, and Susceptibility to Heart Failure in Mice. American Journal of Physiology – Heart and Circulatory Physiology 2002; 282: H2076-H2083.

Shusterman V, Jannetta PJ, Aysin B, Beigel A, Glukhovskoy M, Usiene I. Direct Mechanical Stimulation of Brainstem Modulates Cardiac Rhythm and Repolarization in Humans. J of Electrocardiology 2002; 35: 247-256.

Shusterman V, Aysin B, Ermentrout GB, London B, Schwartzman D. Detecting instabilities of cardiac rhythm. J of Electrocardiology 2003;36: 219-226.

Shusterman V, Goldberg A. Tracking Repolarization Dynamics in Real-Life Data. J of Electrocardiology 2004:37:180-186.

Shusterman V, Barnea O. Slow Rhythms of Peripheral Vasculature and Sympathetic Nervous System Activity in Stress and Biofeedback Relaxation. IEEE Engineering in Medicine and Biology Magazine 2005;24:52-57.

Aysin B, Chaparro LF, Grave I, Shusterman V. Orthonormal-Basis Partitioning and Time-Frequency Representation of Cardiac Rhythm Dynamics. IEEE Transactions on Biomedical Engineering 2005;52:878-889.

Lampert R, Shusterman V, Burg M, Lee F, Earley C,  Goldberg A, McPherson C, Batsford W Soufer R. Effects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors, Journal of Cardiovascular Electrophysiology 2005;16:373-377.

Shusterman V, Goldberg A, London B.Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans. Circulation 2006 Jun 27;113(25):2880-2887.

Reviews, invited published papers, proceedings of conference and symposia, monographs, books and book chapters

Shusterman V. On the role of vasospasm in the genesis of various forms of angina pectoris.  Kardiologya, 1992; 2: 98-100.

Shusterman V, Trofimov O. Application of expert systems for differential diagnostics of cardiovascular diseases.  Proceedings of the 4th International Symposium "Systems Analysis and Simulation", A. Sydow (ed.). Berlin, 1992, p. 647-650. Elsevier Science Publishers B.V.

Shtark M, Shusterman V. The method of "Intellectual Biofeedback". Proceedings of the 24th Annual Meeting of the American Association for Applied Psychophysiology and Biofeedback, Los Angeles, 1993.

Shusterman V.  Computerized symbolic model of cardiovascular regulation for analysis of physiological reactions accompanied by chest pain.  Proceedings of the 25th Annual Meeting of the American Association for Applied Psychophysiology and Biofeedback, Atlanta, 1994, p.156-157.

Shusterman V, Barnea O.  A new method for assessment of stress-related sympathetic reactions.   Proceedings of the 26th Annual Meeting of the American Association for Applied Psychophysiology and Biofeedback, 1995, Cincinnati, Ohio.

Shusterman V. Barnea O.  Skin-temperature variability indicates vascular sympathetic activity Proceedings of the 18th Convention of Electrical and Electronics Engineers in Israel, Tel Aviv, 1995, 4.2.5.

Barnea O, Shusterman V.  Analysis of skin-temperature variability compared to variability of blood pressure and heart rate.  Proceedings of the Convention of Electrical and Electronics Engineers, Montreal, Canada, 1995, 4.3.3.13.

Li C, Shusterman V, Tai C, Anderson KP. Wavelet decomposition of nonstationary heart rate variability. Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, 1997, 85-88.

Aysin B, Chaparro LF, Grave I, Shusterman V. Denoising of nonstationary signals using optimized Karhunen-Loeve expansion. Proceedings of the IEEE International Symposium on Time-Frequency and Time-Scale Analysis, p.621-624, 1998, Pittsburgh, PA.

Shah SI, Shusterman V, Aysin B, Anderson KP. Instantaneous changes in the heart rate variability during head-up tilting revealed by positive time-frequency distribution. Proceedings of the IEEE International Symposium on Time-Frequency and Time-Scale Analysis, 1998:253-256.

Shusterman V, Aysin B, Shah SI, Flanigan S, Anderson KP. Autonomic nervous system effects on ventricular repolarization and RR interval variability during head-up tilt. Computers in Cardiology, 1998,25:717-720.

Aysin B, Chaparro LF, Grave I, Shusterman V. Detection of transients in heart rate variability signals using a time-varying Karhunen-Loeve expansion. IEEE International Conference on Acoustics, Speech, and Signal Processing, 2000 (in press).

Ezekiel S, Alshehri, AA, Hovis RA, Hebert DJ, Shusterman V. Heart rate variability signal processing by using wavelet based multifractal analysis, Proceedings of the IASTED International Conference on Measurement and Control (MECO'2001), 2001.

Shusterman V, Yacobson I. Understanding cardiovascular autonomic control: Results, pitfalls, and perspectives. In: Biofeedback: Theory and Practice. Eds. Shtark M. and Schwatz M. p.151-156,  Novosibirsk, 2002.

Aysin B, Chaparro LF, Shusterman V. Time-frequency analysis of cardiac rhythm to reveal patterns of adaptation to orthostatic challenge. Proceedings of the 25^th International Conference of Engineering in Biology and Medicine Society (EMBS), Cancun, Mexico, 2003.

Shusterman V, Schwartzman D. Neurological basis of atrial fibrillation. In: Innovative Management of Atrial Fibrillation, Zenati M, Schwartzman D, (eds), Blackwell Futura, 2005.

Selected abstracts

Shusterman V, Gottipaty V, Fahrig S, Anderson KP. Heart rate variability preceding the onset of sustained monomorphic ventricular tachycardia. PACE 19: 597, 1996.

Frolov A, Trofimov O, Shtark M, Shusterman V. Phase space as electrocardiogram and pulse wave indicates dynamics of cardiovascular regulation. Biofeedback and Self-Regulation 1996; 21:358.

Shusterman V, Young L, Aysin B, Gottipaty V, Fahrig S, Anderson KP for the ESVEM Investigators. Heart rate variability preceding spontaneous ventricular tachycardia. J Am Coll Cardiol 1997; 29:472A.

Aysin B, Shusterman V, Gravé I, Gottipaty V, Fahrig S, Anderson KP for the ESVEM Investigators. Differences in circadian variations of ventricular tachycardia and premature ventricular complexes. J Am Coll Cardiol 1997; 29:293A.

Konety S, Shusterman V, Shah SI, Gottipaty V, Fahrig S, Anderson KP for the ESVEM Investigators. Dissociation in QT-RR relationship preceding sustained ventricular tachycardia. PACE 1997; 20:1112.

Li C, Shusterman V, Gottipaty V, Fahrig S, Anderson KP for the ESVEM Investigators. Changes in the energy distribution of heart rate variability in patients with chronic sympathetic predominance. PACE 1997; 20: 1104.

Shusterman V, Aysin B, Gottipaty V, Fahrig S, Anderson KP for the ESVEM Investigators. Physiological saturation in the markers of sympathetic activity preceding spontaneous sustained ventricular tachycardia. PACE 1997; 20: 1158.

Anderson KP, Shusterman V, Aysin B, Fahrig S, Gottipaty V. Autonomic nervous system activity before PVC-triggered and nonPVC-triggered spontaneous sustained ventricular tachycardia. Circulation 1997; 96:I-24.

Shusterman V, Konety S, Flanigan S, Shah SI, Fahrig S, Gottipaty V, Anderson KP. Short-term changes in RR and QT-intervals are related to the rate and duration of ventricular tachycardia. Circulation 1997; 96:I-581.

Anderson KP, Shusterman V, Aysin B, Brode S, Gottipaty V, Schwartzman D for the ESVEM Investigators. Time course of heart rate and heart rate variability before spontaneous sustained ventricular tachycardia. J Am Coll Cardiol 1998;31:90A.

Anderson KP, Shusterman V, Aysin B, Brode S, Gottipaty V, Schwartzman D for the ESVEM Investigators. Mismatch of tonic and phasic sympathetic activity precedes spontaneous ventricular tachycardia. J Am Coll Cardiol 1998;31:482A.

Shusterman V, Aysin B, Beigel A, Brode S, Fahrig S, Gottipaty V, Schwartzman D, Weiss R,  Anderson KP for the ESVEM Investigators. Do slow variations in heart rate predict spontaneous initiation of ventricular tachycardia? PACE 1998;21:948.

Shusterman V, Li C, Aysin B, Brode S, Fahrig S, Gottipaty V, Schwartzman D, Weiss R, Anderson KP for the ESVEM Investigators. Circadian changes in the energy distribution of wavelet-transformed heart rate variability. PACE 1998;21:887.

Weiss R, London B, McNamara D, Shusterman V, Buetikofer JA, Brode S, Fahrig S,  Gottipaty V, Schwartzman D, Anderson KP. Familial occurrence of right bundle branch block, ST elevation, and arrhythmia susceptibility. PACE 1998;21:939.

Anderson KP, Shusterman V, Aysin B, Weiss R, Brode S, Schwartzman D, Gottipaty V for the ESVEM Investigators. RR intervals and heart rate variability rise gradually then decline rapidly before the onset of sustained ventricular tachyarrhythmias. J Am Coll Cardiol 1999;33:118A.

Shusterman V, Aysin B, Chaparro L, Gravé I, Brode S, Gottipaty V, Weiss R, Anderson KP, ESVEM Investigators. On-line prediction of ventricular tachyarrhythmias using short-term RR-interval perturbations: comparative analysis of different signal processing techniques. PACE 1999;22:837.

Shusterman V, Aysin B, Flanigan S, Usiene I, Brode S, Gottipaty V, Weiss R, Anderson KP, ESVEM Investigators. Intermediate-term predictors of ventricular tachyarrhythmias. PACE 1999;22:837.

Anderson KP, Shusterman V, Beigel A, Aysin B, Brode S, Gottipaty V, Weiss R, ESVEM Investigators. Changes in ventricular repolarization preceding the onset of spontaneous sustained ventricular tachycardia. PACE 1999:22:837.

Shah SI, Shusterman V, Aysin B, Flanigan S, Cavlovich D, Brode S, Gottipaty V, Weiss R, Anderson KP. Susceptibility to syncope at baseline: a novel approach. PACE 1999;22:757.

Shusterman V, Beigel A, Shah SI, Aysin B, Anderson KP. Changes in autonomic activity and repolarization.  Proceedings of the 24^th Annual Conference of the International Society for Computerized Electrocariology, Nara, Japan, 1999.

Beigel A, Shusterman V, Shah SI, Aysin B, Anderson KP. Measurements of beat-to-beat changes in ventricular repolarization preceding spontaneous tachyarrhythmias in Holter ECGs.  Proceedings of the 24^th Annual Conference of the International Society for Computerized Electrocariology, Nara, Japan, 1999.

Shusterman V, Aysin B, Chaparro LF, Grave' I, Anderson KP. Cumulative dynamics of cardiac cycles predicts initiation of ventricular tachyarrhythmias, Circulation 1999;100:I-656.

Shusterman V, Usiene I, Lee JS, Kubota T, Anderson KP, London B. Ambulatory telemetry monitoring shows progressive increase in ectopic frequency in a TNF-a mouse model of congestive heart failure, Circulation 1999; 100: I-207.

Weiss R, Shusterman V, Beigel A, Aysin A, Cavlovich D, London B, McNamara D, Brode S, Gottipaty V, Anderson KP. Changes in the ST-Isointegral maps in Brugada syndrome family members. J Am Coll Cardiol 2000;35:144A.

Shusterman V, Anderson KP, Ermentrout GB. Cumulative dynamics of cardiac cycles and initiation of reentrant arrhythmias in a continuous 2d model of cardiac tissue. PACE 2000;23:730.

Shusterman V, Aysin B, Weiss R, Gottipaty V, Anderson KP, Schwartzman DS. Changes in the pattern of cardiac cycle dynamics predict initiation of paroxysmal atrial fibrillation. PACE 2000;23:668.

Anderson KP, Beigel A, Shusterman V. Ventricular repolarization and T-wave alternans preceding the onset of spontaneous sustained ventricular tachycardia. PACE 2000; 23:714.

Weiss R, London B, Cavlovich D, Nguyen T, Bedi M, McNamara D, Shusterman V. Changes in repolarization identify affected subjects with Brugada syndrome. PACE 2001; 24:717.

Shusterman V, Usiene I, Aysin B, Lee JS, Feldman AF, London B. Slow rhythm destabilizaion precedes initiation of ventricular arrhythmias in a TNF-α mouse model of congestive heart failure. PACE 2001, 24:690.

Shusterman V, Usiene I, Aysin B, Glukhovskoy M, Jannetta PJ. First evidence of existence of a localized brainstem center of cardiovascular control in humans. J Am Coll Cardiol 2002; 39: 81A-81A.

Shusterman V, Aysin B, Brode S, Schwartzman D, Weiss R, Ganz L. Preventive Properties Of Ventricular Rate Smoothing Revisited. PACE 2002; 24: 641.

Shusterman V, Aysin B, Bazaz R, Brode S, Saba S, Schwartzman D, Ganz L. Slow Changes in the Cardiac Rhythm Envelope and Ventricular Tachyarrhythmias. PACE 2002; 24: 653.

Shusterman V, Kornblit CA, Usiene I, Cavlovich D, Aysin B, McNamara DM, Weiss R, London B. Autonomic nervous system dysfunction in Brugada syndrome. Circulation 2002, 106: 700.

Shusterman V, Warman E, Usiene I, Schaaf K, Schwartzman D. Patterns of Initiation of Paroxysmal Atrial Fibrillation. Circulation 2002, 106: 458.

Shusterman V, Jannetta PJ, Aysin B, Glukhovskoy M, Usiene I. Markers of Central Modification of the Sympathetic Nervous System Activity in Humans. J Am Coll Cardiol 2003; 41: 111A.

Gursoy E, Shusterman V, Antanaviciene K, Aysin B, Usiene I, Shah A, Rayl K, Harrigal C, Feldman AM, London B. Diminished b-Adrenergic Responsiveness of Cardiac Rhythm in a Mouse Model of Heart Failure. Biophysical Journal 2003; 84(2): 422a.

Aysin B, Chaparro LF, Shusterman V. Stable 0.1 Hz Frequency Component of Heart Rate Variability as a Marker of Successful Adaptation to Head-Up Tilt. PACE 2003; 26: 1049.

Shusterman V, Goldberg A. Instability of Cardiac Rhythm and Repolarization as Precursors of Ventricular Tachyarrhythmias. American Heart Association Web site (www.americanheart.org), 2003.

Lampert R, Burg M, Shusterman V, Lee F, Soufer R. Mental Stress and Ventricular Arrhythmias in Patients with Implantable Cardioverter-Defibrillators. American Heart Association Web site (www.americanheart.org), 2003.

Lampert R, Shusterman V, Burg M, Lee F, Earley, Goldberg A, Batsford, McPherson, Soufer R. Psychological Stress Increases Heterogeneity of Repolarization in Patients with Structural Heart Disease and Ventricular Arrhythmias. J Am Coll Cardiol 43: 140A-141A 2004.

Shusterman V, Goldberg A. T-wave Alternans as a Precursor of Ventricular Tachyarrhythmias. PACE 1: S128, 2004.

Shusterman V, Goldberg A. Upsurge in T-wave Alternans and Complex-Form Repolarization Instability Precedes Spontaneous Initiation of Ventricular Tachyarrhythmias in Humans. Circulation 2004;110:667.

Shusterman V, Goldberg A., London B. Adrenergic Stimulation Promotes T-Wave Alternans In A Tnf-a Genetic Mouse Model Of Congestive Heart Failure. Heart Rhythm 2005;2:S142-143.

Williams JL, Ganz L, Shusterman V, London B, Saba S. Higher-Order Polynomial Modeling of Rabbit Epicardial Ventricular Electrograms. Heart Rhythm 2005;2:S217-218.

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